Health services research

Research

Does changed referral options affect the use of MRI for patients with low back pain? Evidence from a natural experiment using nationwide data

  1. Morten Sall Jensen1,2,
  2. Kim Rose Olsen3,
  3. Lars Morsø1,4,
  4. Jens Søndergaard5,
  5. Berit Schiøttz-Christensen1,6

  1. 1The Institute of Regional Health Research, University of Southern Denmark,Odense, Denmark

  2. 2VIVE, The Danish Center of Social Science Research,Copenhagen, UK

  3. 3DaCHE, Institute of Public Health, University of Southern Denmark,Odense, Denmark

  4. 4Centre for Quality, Region of Southern Denmark,Middelfart, Denmark

  5. 5Research Unit of General Practice, Institute of Public Health, University of Southern Denmark,Odense, Denmark

  6. 6Spine Centre of Southern Denmark, Lillebaelt Hospital, Region of Southern Denmark,Middelfart, Denmark
  1. Correspondence to Morten Sall Jensen;mosj{at}vive.dk,morten_sall{at}hotmail.com

Abstract

ObjectivesThis study reports lumbar MRI referral patterns in the Region of Southern Denmark (RSD) and investigates the hypothesis that we will see an increase in imaging rates (MRI rates) following new referral options to lumbar MRI in the RSD in comparison with the other regions in Denmark from 2010 to 2013.

DesignA difference-in-difference (DD) analysis, using general practitioners (GPs) in other regions as control, was used to test if the new referral options had an effect on the MRI rates.

SettingIn 2010, RSD introduced organisational changes affecting the referral options for lumbar MRI. First, the possibility for direct referral to lumbar MRI was introduced GPs, and second, the region gathered all local spine departments into one specialist hospital called the Spine Centre.

ParticipantsWe retrieved all lumbar MRIs performed on patients aged 18 performed on Danish hospitals from 2008 to 2013 using the registries from Statistics Denmark. We use sociodemographic information from all Danish citizens aged 18 aggregated to GP level. Primary and secondary outcome measures: lumbar MRI scans per 1000 capita enlisted with a GP (MRI rates) were calculated based on GPs patient list. Four referral types were made to describe changes in referral patterns.

ResultsIn total 183 389 patients received 240 760 lumbar MRIs in the period. The use of the direct referral option by GPs in the RSD increased by 115% in the period from 2010 to 2013 and accounted for 34% of all referrals (n=6545) in 2013. MRI rates were significantly higher in RSD following the organisational changes (DD 1.389(0.925–1.852) lumbar MRI per 1.000 enlisted with a GP).

ConclusionsIntroduction of organisational changes in RSD as direct referral to lumbar MRI from GPs and chiropractors as well as establishing a Spine Centre increase the lumbar MRI rate in comparison with other regions in Denmark.

  • magnetic resonance imaging
  • public health
  • organisation of health services
  • low back pain
  • MRI

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Strengths and limitations of this study

  • Nationwide registry data including sociodemographic information on all citizens aged 18 .

  • Use of a difference-in-difference design for possible causal inference.

  • The study might underestimate the lumbar MRIs from private hospitals.

Background

The number of lumbar MRI undertaken in the (US Medicare population increased substantially from 1994 to 2006, despite guidelines which discourages routine use of MRI.1–3It was estimated that the use of MRI and other imaging modalities accounted for 7% of the direct treatment costs of low back pain (LBP) in 1998.4

The factors associated with the increased use of MRI in the diagnostics of LBP have been investigated. Research shows that the substantial geographic differences in use of spinal MRI across states in the USA5–8can be explained by differences in local clinical practices,6physician ownership of specialty hospitals,9fee-for-service schemes,10MRI scanner availability11and state median income per capita.12However, these studies were undertaken in a US setting among populations that had limited access to healthcare providers and where a fee-for service incentive affected doctors’ wages. Consequently, more studies are needed on factors impacting the use of lumbar MRI, in other healthcare settings.13–15

In this study, we have the opportunity of using nationwide data and hence evaluating a natural experiment. In 2010, Region of Southern Denmark (RSD) made two organisational changes.

These included, centralisation of regional spine specialist departments across regional hospitals in one spine specialist hospital. Further, general practitioners (GPs) and chiropractors (CP) were given the possibility to directly refer patients with LBP for lumbar MRI without prior referral to the Spine Centre or to office-based specialist doctors. In the support of the organisational changes, RSD implemented a LBP Disease Management Programme (DMP). The centralisation of the hospital occurred in the beginning of 2010, and the hospital were fully operational in mid-2010. The direct referral access was available for the GPs in the first months of 2010. Hence, we expect effects of the reform to be modest in 2010 and to increase in the following years. These changes were unique in Denmark as two of four other regions maintained decentralised spine departments and did not allow for direct referral. To date, the effect of these organisational changes in RSD have not been investigated.

The study investigates the effect of the organisational changes on use of lumbar MRI in the diagnostics of patients with LBP in RSD. Primary outcome is defined as yearly lumbar MRI rates for all individuals aged 18 . As the reform increased the possibilities to refer to lumbar MRI, we hypothesised that the yearly lumbar MRI rates from 2010 to 2013 would increase significantly in RSD compared with the other regions.

Methods

Design

A longitudinal register-based study covering the Danish population aged 18  from 2008 to 2013. The study relies on a natural experiment using RSD as the intervention group. Two regions, Zealand Region (ZR) and the North Denmark Region (NR), maintained their organisation in the study period from 2008 to 2013. Hence, these two regions can act as good indicators of the counterfactual RSD. GPs in RSD, GPs in the Capital Region of Denmark (CR) and the Central Denmark Region (CD) were given the possibility to directly refer patients with LBP for a lumbar MRI in 2010 and 2011, respectively. This allows GPs from CD to act as controls from 2008 to 2010, while GPs from CR are excluded, as they allow referrals from GPs at the same time as RSD, which is why they cannot act as good indicators of the counterfactual development in RSD if RSD had not made the organisational changes.

Primary outcome

The primary outcome is yearly lumbar MRI per 1000 enlisted with a GP.

Setting

In Denmark, five decentralised administrative regions, including 98 municipalities, manage the tax founded healthcare system.16Each region has a public elected council and is autonomously managing secondary healthcare services. All services provided at hospitals and office-based physicians are free of charge, while services at physiotherapists and CPs involve co-payments from the patient. GPs in Denmark have a unique patient list (GP list) of citizens, to whom the GP solely provided services. The GP list size is on average 1600 patients, and 98% of all Danes are enlisted at one of the 2,200 GP clinics in Denmark.16

Data sources

The study used data from the registries at Statistics Denmark (DST), a governmental institution providing data for research purposes.17All registries are linkable at the individual level, using the personal civil registration number (CPR number), which are given to all Danish citizens at birth.18 19The study includes data from the following registries:

The Danish National Patient Registry (NPR),20 21includes information on diagnosis coded according to the International Classification of Disease (ICD-10) and procedure and surgery codes (Healthcare Classification System (SKS codes)). All NPR records are unique, due to a NPR serial numbers (unique to each patient’s continuum of care at a hospital) and patients’ CPR numbers.

The Danish National Health Service Register for Primary Care22includes all contacts to the primary sector healthcare providers including GPs, CP, physiotherapists and office-based specialist doctors. The GP list and GP list size were generated by combining the unique GP id with the CPR number from patients receiving most of their services from the GP id.23GPs with patient list size less than 300 patients were deleted as they are hypothesised to be GPs either starting up or closing down the practice. Those citizens with no information of GP id in one of the study years were allocated to a hypothetical GP id generated for each region.

Danish National Prescription Registry includes information on all prescription based analgesic drugs sold at Danish primacies.24We identified analgesic drugs according to the Anatomical Therapeutic Chemical classification (ATC) code.25Analgesic drugs included ATC code NN02A and NN02B; tablet cans with >100 pills of paracetamol and ibuprofen, synthetic opioids and opioids.

We further retrieved registers on income,26education,27job and socioeconomic status,28civil status18and demographics18from DST.

Definition of lumbar MRI

This study included data for lumbar MRI (SKS code: UXME30).21Each MRI scan performed at a public hospital is recorded in NPR. Lumbar MRIs performed on a private hospital are recorded in the NPR if they are subsidised by the government. Patients with multiple spine MRI registrations on the same NPR serial number were identified and the UXME30 code was retained for analysis. If patients showed two or more UXME30 codes for the same day only one remained.

Definition of referral mode

A referral mode variable was defined based on two variables from the NPR: referral directly from the GP (1), directly from the CP or initiated by private insurance (2), directly from the office-based specialist doctors (3) and from the hospital department (4). Before 2010, we observe referrals to lumbar MRI from GPs. These are recoded into hospital registrations.

Analyses strategy

The impact on MRI rates of the well-defined organisational changes in 2010 in RSD, is analysed as a natural experiment. The change in the other regions are used as control under the assumption that the development of MRI rates in the control regions are a good indicator of how the MRI rates would have developed in RSD in the absence of the organisational changes.

We hypothesise that the two referral options (direct GP referral and referral to the Spine Centre) drives any change in use of lumbar MRI. As patients have not chosen to live in RSD based on the access to MRI, the assumption behind our analyses strategy is that we can interpret patients as randomly assigned to a GP who by construct of the natural experiment happen to have access to the organisational changes (RSD) or not (control regions). We therefore included GPs from the ZR and the NR as controls for all years in the analysis. GPs from the CD are included from 2008 to 2010, as they had the possibility to directly refer patients with LBP for a lumbar MRI in 2011. GPs from the CR were excluded as controls.

We use a difference in difference (DD) model to analyse the effect of the reform. The DD model estimates the effect of organisational changes by assuming that the counterfactual development in the lumbar MRI rates in the treatment group (ie, RSD) could be approximated by the development in the lumbar MRI rates of the other regions.29For the control group to match the approximation of the counterfactual development in lumbar MRI rates in RSD the model, we rely on an assumption that there was a common trend in lumbar MRI rates before the interventions. The common trend assumption was visually inspected. Furthermore, we estimated the effects of the reform year by year for 2010, 2011, 2012 and 2013 and made a placebo test by testing for an effect of the reform before it was implemented—that is, testing for an increase in lumbar MRI rates from 2008 to 2009. This placebo test is an indirect test of the common trend. The DD approach by definition control for all time constant heterogeneity between GPs in RSD and the controls but if we expect time-varying differences occurring over time we need to add covariates. Hence, second assumption behind our approach is that there were no time-varying unobservable covariates that could explain differences in selection into a referral to lumbar MRI between GPs and between regions.29Hence, we generally assume that citizens’ need for lumbar MRI are identical among regions after controlling for observable patients’ characteristics and supply factors related to LBP treatment did not change over time on the regional level. A limitation of our data set is that we only have 2 years of observation before the organisational changes, which makes the validation of the common trend assumption hard to assess. As a consequence, we supplemented the DD analysis with two robustness checks. First, we made a replication of the analysis using quarterly data instead of annual data. This gives eight pretreatment observations, which allow for a better assessment of the common trend. Second, we estimate the treatment effect using propensity score matching (PSM), an approach that does not rely on the common trend assumption but on common support.30–32

Statistics

The DD model is implemented using a parametric ordinary least squares regression model with robust SEs and clustering for GP id. We aggregated the individual level sociodemographic data to GP level. This allowed for analysis using information from the sociodemographic composition of the GPs’ lists to account for any time-varying patient characteristics that is associated with LBP and therefore explain differences in GPs’ referral to lumbar MRI. A supplementary advantage of using the GP as analytical level is that we in this way obtain an unbalanced panel data structure of our data set, with one observation per unique GP per year. As a robustness check, we organise data in quarterly observations and reassess the DD model using 24 quarterly observations rather than seven annual observations per GP. We further use PSM with nearest neighbour with calliper equal to one-fourth of the SD on the propensity scores. TheSupplementary file 1gives detailed information on the robustness check using quarterly data and PSM.

The changes in referral modes were graphed for RSD (seefigure 1). To show dynamic year effects of the models, 2009 was used as preintervention and each intervention year was used as the postintervention year, in four DD regression models—one for each post treatment year (2010, 2011, 2012 and 2013). To test if the trend in MRI rates were not different between RSD and controls before the programme, we tested for a treatment effect in 2009 using 2008 as base year. The five models used the variables as in the adjusted models and were analysed using both control groups. The DD estimates and the 95% CI were graphed (the control regions were the x-axis). Tables reported number (N), means, SD, unpaired t-test and percentages (%). All analyses were performed using STATA Release V.13 and graphics and tables were performed in Microsoft Excel 2010 (Microsoft Corporation).

Figure 1

Changes in the referral patterns to lumbar MRI in Region of Southern Denmark from 2008 to 2013 using a 100% stacked curve diagram. GP, general practitioners.

Covariates

The unadjusted models included the following variables: pre-2009 and post-2009 (0=2008–2009, 1=2010–2013) and intervention and control regions (1=RSD and 0=ZR, NR, CD).

The adjusted models add time-varying covariates to the above variables. This is done to avoid that any observed change in RSD after the change is simply due to changes in the characteristics of the citizens over time—for example, the citizens in RSD over time becomes more prevalent to LBP than citizens in control regions. All covariates included, except GP list size, were made as proportions of enlisted patients with characteristic X divided with the GP list size. Patients characteristics X included; age 18–59, citizens in a full-time job, income DKK 0–399 000 or missing, women, citizens living as singles and Charlson comorbidity index score332 , patients with vocational education, patients using a prescription on an analgesic drug at a pharmacists, patients having a visit at a physiotherapist, patients having a visit at a CP and patients visiting an office-based specialist doctor (rheumatologist, neurologist, orthopaedics and radiologist). Covariates are seen intable 1.

Table 1

Differences in proportions of patients enlisted at a GP from either intervention or control regions for preintervention years (2008 and 2009 combined)

Patient and public involvement

Patients were not involved in the study.

Ethics

The Danish Data Protection Agency approved this study (Journal number 15/14594). The study is based on registry data, which does not require ethics approval in Denmark (Act on Research Ethics Review of Health Research Projects § 14, sec. 2http://www.nvk.dk/english/act-on-research10.02.2017).

Results

During the study period, 183 389 patients were assessed with 240 760 lumbar MRIs. Of those 27% (63 982 lumbar MRIs) were performed on private hospitals.

The figure 1 shows changes in the rates of referrals for lumbar MRI in the RSD. MRI referrals directly from GPs accounted for 18% (n=3044) of all referrals in 2010. In the subsequent 3 years, the rate of MRI referrals directly from the GP increased to 115% (n=6545) and accounted for 34% of all of the MRI referrals in 2013. MRI referrals from office-based specialists (rheumatologist or orthopaedics) decreased from 2008 (n=1916, 16%) to 2013 (n=464, 2%). MRI referrals from CPs or from a private insurance decreased from 2008 (n=748, 6%) to 2011 (n=220, 1%). MRI referrals from hospital-based doctors increased from 2008 (n=9262, 77%) to 2012 (n=12 487,71%).

The common trend was visually inspected usingfigure 2, showing unadjusted average regional lumbar MRI rates for GPs in RDS and the control regions. Lumbar MRI rates for RSD increased each year starting from 14.29 lumbar MRI per 1000 enlisted with a GP in 2008 to 21.13 lumbar MRI per 1000 enlisted with a GP in 2013. The average lumbar MRI rates for three control regions increased from 7.79 lumbar MRI per 1000 enlisted with a GP in 2008 to 11.48 lumbar MRI per 1000 enlisted with a GP in 2012 and 2013. To capture any differences in time-varying trends, we included characteristics of the GP patient list, seen intable 1. The table show that there are statistical differences for 8 of the 12 included covariates between GPs in RSD and control group regions in the pre-intervention years. However, the differences are small between the patient characteristics of the GPs’ lists in RSD and GPs’ lists in control group regions.

Figure 2

Lumbar MRI rates for RSD and the control regions from 2008 to 2013. GP, general practitioner; RSD, Region of Southern Denmark, Control (the Zealand Region, the Central Denmark Region and the North Denmark Region).

The results of the DD analyses of the lumbar MRI rates per 1000 enlisted with GPs in RSD compared with GPs in the control group are shown intable 2. After the organisational changes in RSD, the lumbar MRI rates increased significantly compared with control groups, for both models ranging from 1.39 (95% CI 0.93 to 1.85) to 1.83 [95% CI 1.37 to 2.29) lumbar MRIs per 1000 enlisted with a GP.

Table 2

DD and PSM estimates from unadjusted and adjusted models with RSD and the control regions

The table 2 also present the robustness checks using DD with quarterly data and PSM (see online supplementary table A.1for DD results and online supplementary table A.2for PSM results in the supplementary material). The model with quarterly data shows a significant increase in quarterly MRI of 0.43, which is at a comparable level as the model using annual data when multiplying with four. The PSM model, however, shows quite higher effects. This may rest on the fact that RSD generally is at a higher level of MRI throughout the period of observation and that the PSM approach is less effective in taking this into account. The PSM result indicates that the DD makes a conservative estimate of the effect. We refer to the online supplementary table A3for bias reductions of PSM model and online supplementary figure A2for common support in supplementary material.

The dynamic year effects for both models are seen infigure 3. Thefigure 3indicates that the common trend assumption support is fulfilled, as a hypothesised treatment effect before the intervention (ie, in 2009) occurred (placebo effect) is insignificant. This test is also insignificant in the model using quarterly data and hence eight pretreatment observations (see online supplementary table A1).

Figure 3

Dynamic year effects using the adjusted model, with multiple difference in difference estimates with 2009 as the preintervention period and all postintervention years for Region of Southern Denmark and the control regions. b, beta estimates from the difference in difference analysis; min95, lower bound of the 95% CI of the beta estimate; max95, upper bound of the 95% CI of the beta estimate.

Dynamic year effects for postintervention years were positive and significant for all years, with an observed increase positive trend of the estimates, indicating that the effect of the organisational changes increases over time (figure 3).

Discussion

This study showed that establishing a Spine Centre in the RSD and introducing direct referrals for lumbar MRI by GPs was associated with an increase in the use of lumbar MRI (compared with that of other regions) in the years following the 2010 changes. On average, the increase was between 1.39 and 1.83 lumbar MRI per 1000 enlisted with GPs in RSD involving an increase in lumbar MRI of between 1400 and 1800 additional scans compared with the other regions. The use of the direct referral option by GPs in the RSD increased by 115% in the period from 2010 to 2013, indicating that the GP adopted the ne w opción de referencia.

Como en otros estudios de EE. UU.,7 encontramos variaciones geográficas en el uso de la RM lumbar entre las regiones de Dinamarca. La razón de la diferencia en el uso de la RM lumbar entre las regiones aún no está clara. Algunos puntos apuntan a un interés especial en el dolor de espalda realizado por médicos especialistas en RSD, que se relaciona con diferentes prácticas clínicas regionales, que se han encontrado en estudios en los Estados Unidos.6 11Es poco probable que la relación entre el uso de MRI y los incentivos médicos9 10explique la Diferencias en un entorno danés. Primero, los médicos del hospital público reciben un salario anual fijo, por lo que no tienen incentivos para referir a los pacientes. En segundo lugar, los hospitales públicos realizaron el 74% de todas las exploraciones.

El aumento en las derivaciones para RMN lumbar tras el cambio en el acceso de derivación de GP a RMN lumbar en la DSR en 2010 es notable . Los médicos de cabecera en el RSD claramente comenzaron a usar la nueva opción de referencia de inmediato y el uso de la opción de referencia aumentó en un 115% de 2010 a 2013. Este cambio podría indicar una reducción en el umbral para una referencia de MRI. Podría haber numerosas razones para el uso de referencias directas a la RM lumbar, incluidas las demandas de los pacientes35 36y el deseo de los médicos para proporcionar garantías rápidas a los pacientes con LBP.36El hecho de proporcionar una seguridad rápida a los pacientes podría evitar nuevas visitas costosas a médicos especialistas y reducir futuros costos de tratamiento. Sin embargo, estudios anteriores han demostrado que las referencias de resonancia magnética lumbar de médicos de cabecera son inapropiadas en hasta el 50% de los casos cuando se juzgan según las pautas.10 37–39Además, se ha demostrado que el uso inadecuado de la RM lumbar está asociado con un mayor uso de opioides, mayores costos de atención médica y un bajo impacto en el alivio del dolor o la recuperación funcional después de 6 meses en pacientes con LBP específica, sin patologías graves como el cáncer, la compresión de la raíz nerviosa, la cauda equina, la radiculopatía y la ciática.3 5 40–46 Se necesitan más estudios para investigar si se encuentran las mismas asociaciones en esta configuración.

Fortalezas y limitaciones

Este estudio utilizó estimaciones de DD para captar el efecto de los cambios organizativos y LBP DMP en RSD. DD es un diseño popular para la evaluación de cambios de políticas, como se usa ampliamente en las ciencias sociales.29DD se basa en el el supuesto de una tendencia común en el período de pretratamiento para los resultados de interés. Esta suposición parece cumplirse en el presente estudio. Sin embargo, una clara limitación de nuestro conjunto de datos es que tenemos un corto período de pretratamiento. Como consecuencia, hemos utilizado DD en los datos trimestrales y en el análisis de PSM para verificar la solidez de los resultados. Ambos análisis respaldan los hallazgos y, como creemos que el enfoque de DD es el más conservador, nos atenemos a este modelo como nuestro caso base. Los detalles sobre el modelo de robustez se encuentran en elArchivo complementario 1en línea.

Las referencias de médicos de cabecera se ven de 2008 a 2009 y se recodifican a referencias de hospitales, ya que no tuvieron la oportunidad de derivar a pacientes con LBP para una RM lumbar. Puede haber varias explicaciones para estos registros. En primer lugar, los registros con referencias de GP en 2009 pueden ser una prueba del sistema de referencia electrónico, que se utiliza en la comunicación entre médicos de cabecera y hospitales. En segundo lugar, las referencias de los médicos de cabecera pueden interpretarse en relación con los médicos de cabecera que derivan a pacientes con LBP para una consulta en atención secundaria, donde los médicos de cabecera derivan al paciente para una RM lumbar el mismo día que la consulta. Esto le permite al médico especialista en el hospital evaluar la RM lumbar en la consulta del hospital y reducir las visitas al hospital para el paciente.

El estudio se basó en datos de la nueva actualización 2018 de la NPR en Statistics Denmark.47Esto permitió obtener los datos más recientes de todas las personas mayores de 18 años. De la población de Dinamarca. La granularidad de los datos permite una precisión invisible de los análisis realizados a nivel de país.

Conclusiones h2>

Tras la introducción de los cambios organizativos de RSD en 2010, la tasa de resonancia magnética lumbar aumentó significativamente en comparación con las otras regiones de Dinamarca. La cuestión de si el mayor uso de la RM lumbar es beneficioso para los pacientes con LBP de RSD (en comparación con el de otras regiones) requiere investigaciones adicionales.

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